Idiosyncratic drug-induced agranulocytosis: Possible mechanisms and management
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چکیده
منابع مشابه
Drug-induced aplastic anaemia and agranulocytosis. Incidence and mechanisms.
Aplastic anaemia and agranulocytosis are uncommon but serious adverse effects of drug therapy. They result from an adverse interaction between the drug and the haemopoietic pathway in certain susceptible individuals. The nature of this idiosyncratic interaction differs for different drugs and possibly for different individuals. In some instances an immune mechanism might be implicated, in other...
متن کاملAntithyroid drug-induced agranulocytosis.
Thyrotoxicosis is a common endocrine disorder. Antithyroid drug therapy is the standard treatment for this disease, especially in young women of reproductive age. A serious side effect of antithyroid drug use, however, is agranulocytosis. We report on two patients with antithyroid drug-induced agranulocytosis. Both patients presented with fever and severe neutropenia. The administration of gran...
متن کاملAntithyroid drug-induced agranulocytosis.
Antithyroid drugs are widely used to treat hyperthyroidism, especially Graves' disease, but they tend to cause agranulocytosis, which increases the mortality rate. Granulocyte colony-stimulating factor decreases the duration of recovery from agranulocytosis. We retrospectively studied cases of antithyroid drug-induced agranulocytosis over the past 10 years in a northern Taiwan medical center. A...
متن کاملImmune mechanisms of idiosyncratic drug-induced liver injury
Society of Toxicology. Abstract no. 1503.[37] Zimmerman HJ. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. Lippincott Williams & Wil-kins. 1999. [38] Luyendyk JP, Maddox JF, Cosma GN, Ganey PE, Cockerell GL, Roth RA. Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats. J Pharmacol Exp Ther 2003; 3...
متن کاملPopulation-based drug-induced agranulocytosis.
BACKGROUND Since the publication of a major international case-control study on the risk of agranulocytosis associated with the use of medicines in the 1980s, many new drugs have been introduced in therapeutics. METHODS Seventeen units of hematology contribute to the case-control surveillance of agranulocytosis and aplastic anemia in Barcelona, Spain. After a follow-up of 78.73 million person...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2009
ISSN: 0361-8609,1096-8652
DOI: 10.1002/ajh.21433